| Names | Period of Service | Title | Photo | |
| 1 | Hon.Boahene Yeboa Afari | 1956-1960 | Minister |  |
| 2 | Hon. F.Y. Asare | 1960-1960 | Minister |  |
| 3 | Hon. Kojo Botsio | 1960-1962 | Minister |  |
| 4 | Hon. L.R. Abavana | 1962-1962 | Minister |  |
| 5 | Hon. Krobo Edusei | 1963-1965 | Minister |  |
| 6 | Hon. F.A. Jantuah | 1966-1966 | Minister |  |
| 7 | Hon. Jacob Ofori-Torto | 1967-1968 | Commissioner |  |
| 8 | Hon. Albert Adumakoh | 1968-1969 | Commissioner |  |
| 9 | Hon. Prof. Twum Barimah | 1969-1972 | Commissioner |  |
| 10 | Hon. Dr. Kwame Safo-Adu | 1972-1973 | Minister |  |
| 11 | Hon. Major Gen. D.K. Addo | 1973-1975 | Commissioner |  |
| 12 | Hon. Col.F.G. Bernasko | 1975-1976 | Commissioner |  |
| 13 | Hon. Col. Paul Nkegbe | 1977-1979 | Commissioner |  |
| 14 | Hon. Brig. N.A Odartey Wellington | 1979-1979 | Commissioner |  |
| 15 | Hon. Col. S.M. Akwagyiram | 1979-1980 | Commissioner |  |
| 15 | Hon. Abayifa Karbo | 1979-1979 | Commissioner | |
| 17 | Hon. E.Kwaku Twumasi (act) | 1980-1981 | Minister |  |
| 18 | Hon. Dr. E.k. Andah | 1982-1982 | Minister |  |
| 19 | Hon. Nelson Yaw Agbesi | 1982 | Minister |  |
| 20 | Hon. Prof. Botei Doku | 1982-1983 | Secretary |  |
| 21 | Hon. John Ndebugre | 1984-1985 | Secretary |  |
| 22 | Hon. I.K. Adjei-Marfo | 1985-1986 | Secretary |  |
| 23 | Hon. Commodore S.G. Obimpeh (Rtd) | 1986-1992 | Secretary |  |
| 24 | Hon. Ibrahim l. Adam | 1992-1996 | Minister |  |
| 25 | Hon. Commodore S.G. Obimpeh (Rtd) MP | 1998-2001 | Minister | |
| 26 | Hon. Dr. Kwabena Agyei MP | 1997-1998 | Minister |  |
| 27 | Hon. J H Owusu Acheampong MP | 1998-2001 | Minister |  |
| 28 | Hon. Maj. Courage E.K. Quashigah (Rtd) | 2001-2005 | Minister |  |
| 29 | Hon. Ernest Akobour Debrah MP | 2005-2009 | Minister |  |
| 30 | Hon. Kwesi Ahwoi | 2009-2013 | Minister |  |
| 31 | Hon. Clement Kofi Humado | 2013-2014 | Minister |  |
| 32 | Hon. Fiifi FIavi Franklin Kwetey | 2014-2016 | Minister |  |
| 33 | Hon. Alhaji Mohammed Muniru Limuna | 2016-2017 | Minister |  |
